Alone in a Crowded Room

In the Crowded HIV Market, There's Room for Innovation.

As researchers seek more-effective, safer medications to treat human immunodeficiency virus, the focus has shifted to fixed-dose, single-tablet combinations.

Diffusion in a crowded environment.

We analyze a pair of diffusion equations which are derived in the infinite system-size limit from a microscopic, individual based, stochastic model. Deviations from the conventional Fickian picture are found which ultimately relate to the depletion of resources on which the particles rely. The macroscopic equations are studied both analytically and numerically, and are shown to yield anomalous ...

Life in a crowded world.

Introduction Macromolecules are present as soluble species and/or structural arrays at total concentrations of up to several hundred grams per litre in essentially all physiological compartments. Although local composition varies widely between different systems, it is evident that most macromolecular reactions and processes in vivo—as opposed to typical experiments in vitro in which the total ...

Calcineurin in a Crowded World

Calcineurin is a Ser/Thr phosphatase that is important for key biological processes, including immune system activation. We previously identified a region in the intrinsically disordered regulatory domain of calcineurin that forms a critical amphipathic α-helix (the "distal helix") that is required for complete activation of calcineurin. This distal helix was shown to have a Tm close to that of...

Comment: Rethinking the Origins of Agriculture A Conversation on Agricultural Origins Talking Past Each Other in a Crowded Room